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Principal Investigators: 
Mrs. M.J. Roobol, Prof. Dr.
+31 10 70 33 271
Mr. C.H. Bangma, Prof. Dr. M.D.
+31 10 70 33 607
Database management:
Mr. Henk Luiting M.D.
+31 10 70 33 571
Site management:
Mr. W. Roobol
Inclusion criteria
  Thu 14 Sep 2006 (13163 )
Criteria for inclusion in PRIAS:
1) Histologically proven adenocarcinoma of the prostate.

2) Men should be fit for curative treatment.

3) PSA-level at diagnosis ≤ 10 ng/mL.

4) PSA density (PSA D) less than 0.2.

5) Clinical stage T1C or T2.

6) Gleason score 3+3=6.

7) One or 2 biopsy cores invaded with prostate cancer:

a.
If an MRI, including targeted biopsies on positive lesions, is done at inclusion, there is no limit in the number of positive cores (that is, more than two, and no limit in the % of cancer present in the cores).

b.
If saturation biopsies (either transperineal or transrectal) are done 15% of the cores can be positive with a maximum of 4. (i.e. <20 cores 2 cores can be positive (standard), 20-26 cores 3 cores can be positive, >26 cores 4 cores can be positive) (all other inclusion criteria still apply).

8) Participants must be willing to attend the follow-up visits.

Note: Patients with biopsy Gleason score 3+4 can be followed outside the actual PRIAS protocol.
The patient should be at least 70 years old and should have evidence of limited disease (maximum 10% tumor involvement per biopsy core, maximum 2 cores positive).
Risk reclassification is defined as any upgrading in Gleason score and/or more than 2 positive cores at repeat biopsy.

Exclusion-criteria:
1) Men who can not or do not want to be radiated or operated.

2) A former therapy for prostate cancer.




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